Five authoritative scientists including Linda Partridge, founding director of the Max Planck Institute for Aging in Germany, have updated and improved the cellular aging markers based on aging research in the past 10 years, published in the top science journal published an authoritative review of the "12 Signs of Aging", providing K2LT'S-Longevity Technology Company with theoretical support for the research and development of anti-aging products!

The field of aging research has identified 12 markers that represent common characteristics of aging in different organisms. Sign of cellular senescence: DNA methylation

DNA methylation regulates gene transcription, imprinting, X chromosome inactivation and defense against exogenous Invasion of genetic material plays an important role in cell differentiation, embryonic development, environmental adaptation, and disease occurrence and development. It is one of the current hot areas of epigenetic research.

DNA methylation is a form of chemical modification of DNA that can change the DNA sequence without changing it. Genetic manifestations. A large number of studies have shown that DNA methylation can cause changes in chromatin structure, DNA conformation, DNA stability and the interaction between DNA and proteins, thereby controlling gene expression. DNA methylation capsules maintain the stability of genetic information, gene expression patterns and stability, embryonic development and selective expression of alleles.

There are more than 200 different types of cells in the human body. Not only do they have different DNA methylation profiles related to cell differentiation, but also Adaptation-related DNA methylation profiles that change with changes in environmental factors and age. Obviously, compared with the genome, the epigenetic group such as the DNA methylome in the human body is more complex and diverse, and the research work is particularly arduous. How do human ESCs with identical DNA genome sequences differentiate into different cells? How does DNA methylation work in coordination with other epigenetic networks? How do these networks effectively adapt to changes in different living environment factors? What role do these networks play in the development of disease? Which ones can be used for disease prevention, diagnosis and treatment? These are hot questions that still need to be elucidated.

Epigenetic phenomena are extremely complex. On the one hand, outstanding scientists need to continue to work creatively to reveal epigenetic phenomena such as DNA methylation. The basic rules for the initiation, expansion, maintenance, and removal of genetic networks. On the other hand, considerable resources need to be invested to develop sensitive, reliable, and low-cost single-cell omics analysis technologies to analyze the role of DNA methylation in affecting disease occurrence and evaluating environmental factors. Safety, role and mechanism in increasing crop yield and disease resistance, and studying its potential application value. With the reduction of the cost of deep sequencing and the emergence of various data mining software, the study of comparative epigenomics between different types of cells in animals and between different species is expected to flourish, and the evolutionary formation mechanism of DNA methylation is expected to flourish. will hopefully be revealed.

Using circulating MGMT methylation to predict sensitivity to methylurea chemotherapy drugs begins clinical trials; DNA methylation blockade The agent deoxyazacytidine has been approved for the clinical treatment of myeloid dysplasia syndrome and has begun to expand to other tumor types. China is a country with large disease resources and human resources. The current upsurge in translational medicine research has led to continuous research on the relationship between DNA methylation and diseases across the country. A number of DNA methylation products with clinical use are expected to emerge in the near future.

K2LT'S follows the trend. A patent was issued for the application of a DNA methylation composition. It's like "enlightenment", and enlightenment is sometimes like a sudden inspiration, sometimes like finding the right number on the safe, the kind of thing that is about to happen but makes the right choice.

DNA methylation, using epigenetics and potential therapeutic targets, abnormal DNA methylation and histone acetylation contribute to disease play a driving role in its occurrence and development. Since epidermal modification is a reversible process, epidermal modification changes in disease states provide good targets for treating diseases. New drugs that modulate methylation levels and acetylation status are gradually becoming available.

DNA methylation uses epigenetics and potential therapeutic targets, combining betaine, folic acid, wolfberry polysaccharide, and black pepper extract , effectively maintain the stability of genetic information, prevent DNA methylation, and provide the human body with collagen and natural mineral nutrients, embryo development and selective expression of alleles.

DNA methylation is an important means of regulating gene expression. It plays a vital role in the suppression of living and parasitic DNA sequences, the stability of genome structure, genetic imprinting, embryonic development, and the occurrence and development of tumors and diseases. In addition, abnormal changes in DNA methylation status are common in various tumors, and abnormal DNA methylation status is one of the important characteristics of tumors. DNA methylation compositions maintain the stability of genetic information, gene expression patterns and stability, embryonic development and selective expression of alleles.

12 major applications of K2LT'S in cellular anti-aging: altered intercellular communication, cellular senescence, uncontrolled nutrient sensing, loss of protein homeostasis, Disable macroautophagy, dysbiosis, epigenetic changes, genomic instability, mitochondrial dysfunction, stem cell failure, telomere loss, and chronic inflammation; apply the most cutting-edge life science and technology to provide consumers with safe and efficient pure natural, anti-cell Aging high-tech products, intelligent combination + technological formula, significantly improve human life span.